Acute phase protein
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(Redirected from Acute phase response)
Acute-phase proteins are a class of proteins that are synthetized in the liver in response to inflammation. This response is called the acute-phase reaction. Image:Segmented neutrophils.jpg In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL-1, IL-6 and IL-8, and TNF-alpha.
The liver responds by producing a large number of acute-phase reactants, most notable of which are:
- C-reactive protein
- Mannan-binding lectin
- Alpha 1-antitrypsin
- Alpha 1-antichymotrypsin
- Alpha 2-macroglobulin
- some coagulation factors (Fibrinogen, prothrombin, factor VIII, von Willebrand factor, plasminogen)
- Complement factors
- Ferritin
- Serum amyloid P component (see amyloid)
Measurement of acute phase proteins is a useful marker of inflammation in both medical and veterinary clinical pathology.fr:Protéine de phase aiguë