Fabry's disease
From Free net encyclopedia
Template:DiseaseDisorder infobox (ILDS E75.25) |
ICD9 = Template:ICD9 | ICDO = | Image = | Caption = | OMIM = 301500 | OMIM_mult = | MedlinePlus = | eMedicineSubj = neuro | eMedicineTopic = 579 | DiseasesDB = 4638 |
}} Fabry's disease (also known as Anderson-Fabry disease and Angiokeratoma corporis diffusum) is a lysosomal storage disease caused by deficient alpha galactosidase.
Symptoms
Some of the pathological symtoms includes skin lesions, febrile episodes, burning in extremities. Skin lesions are painless elevated papules that appear all over body. Ocular involvement may present and showing vortex keratopathy. Death in early adulthood usually due to renal failure because of proteinuria induced hypertension.
Treatment
Treatment of Fabry's disease until recently was just symptomatic. This is changing with the drugs Agalsidase alpha (Replagal) and Agalsidase beta (Fabrazyme®). Problematic is that the cost of the drugs (approximately $170,000 US a year/patient) remains a barrier to many patients in some countries.