Neurospora crassa

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{{Taxobox | color = lightblue | name = Neurospora crassa | regnum = Fungi | phylum = Ascomycota | classis = Ascomycetes | ordo = Sordariales | familia = Sordariaceae | genus = Neurospora | species = N. crassa | binomial = Neurospora crassa | binomial_authority = Shear & B.O. Dodge }} Neurospora crassa is a type of red bread mold of the phylum Ascomycota. The genus name, meaning "nerve spore" refers to the characteristic striations on the spores that resemble axons.

N. crassa is notable for its use as a model organism in science because it is easy to grow and has a haploid life cycle that makes genetic analysis simple since recessive traits will show up in the offspring. Neurospora was used by Edward Tatum and George Wells Beadle in their experiments for which they won the Nobel Prize in Physiology or Medicine. Beadle and Tatum exposed N. crassa to x-rays, causing mutations. They then observed failures in metabolic pathways caused by errors in specific enzymes. This led to the "one gene, one enzyme" hypothesis that states that specific genes code for specific proteins.

In the 24 April 2003 issue of Nature, the genome of N. crassa was reported as completely sequenced. The genome is about 43 megabases long and includes approximately 10,000 genes. Currently there is a project underway to produce mutant knockouts for every gene in the genome of N. crassa. These mutants are provided at an extremely low price in return for any research information gathered on them.

In its natural environment, N. crassa lives mainly in tropical and sub-tropical regions. It can be found growing on dead plant matter after fires.


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References

  • {{Harvard reference 
| Surname1=Perkins
| First1=D
| Surname2=Davis
| First2=R
| Year=2000
| Title=Evidence for Safety of Neurospora Species for Academic and Commercial Uses
| Periodical=APPLIED AND ENVIRONMENTAL MICROBIOLOGY
| Volume=66 (12):5107-5109
| Date=Dec, 2000
| URL=http://aem.asm.org/cgi/reprint/66/12/5107.pdf

}}. PMID 11097875

  • {{Harvard reference 
| Surname1=Osherov
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| Surname2=May
| First2=GS
| Year=2001
| Title=The molecular mechanisms of conidial germination
| Periodical=FEMS Microbiol Lett
| Volume=199(2):153-60
| Date=May 30, 2001

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  • {{Harvard reference 
| Surname1=Froehlich
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| Surname3=Vierstra
| First3=RD, Loros J & Dunlap JC
| Year=2005
| Title=Genetic and molecular analysis of Phytochromes from the filamentous fungus Neurospora crassa
| Periodical=Eukaryot Cell
| Volume=4(12):2140-52
| Date=December 2005

}}. PMID 16339731

  • {{Harvard reference 
| Author=Horowitz, NH
| Last=Horowitz
| First=NH
| Year=1991
| Title=Fifty years ago: the Neurospora revolution
| Periodical=Genetics
| Date=April 1991
| URL=http://www.genetics.org/cgi/reprint/127/4/631

}}. PMID 1827628

  • {{Harvard reference 
| Surname1=Horowitz
| First1=NH
| Surname2=Berg
| First2=P
| Surname3=Singer
| First3=M, Lederberg J, Susman M, Doebley J & Crow JF.
| Year=2004
| Title=A centennial: George W. Beadle, 1903-1989
| Periodical=Genetics
| Volume=166(1):1-10
| Date=January 2004
| URL=http://www.genetics.org/cgi/content/full/166/1/1

}}. PMID 15020400

  • {{Harvard reference 
| Surname1=Kaldi
| First1=K
| Surname2=Gonzalez
| First2=BH
| Surname3=Brunner
| First3=M
| Year=2005
| Title=Transcriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output
| Periodical=EMBO Rep
| Date=December 23, 2005

}}. PMID 16374510

  • {{Harvard reference 
| Author=Pittalwala, Iqbal
| Last=Pittalwala
| First=Iqbal
| Year=2003
| Title=UC Riverside scientists contribute to study that unveils genome sequence of bread mold
| Periodical=Newsroom (University of California, Riverside)
| Date=April 29, 2003
| URL=http://www.newsroom.ucr.edu/cgi-bin/display.cgi?id=573

}}.

  • {{Harvard reference 
| Surname1=Ruoff
| First1=P
| Surname2=Loros
| First2=JJ
| Surname3=Dunlap
| First3=JC
| Year=2005
| Title=The relationship between FRQ-protein stability and temperature compensation in the Neurospora circadian clock
| Periodical=Proc Natl Acad Sci USA 
| Date=December 6, 2005

}}. PMID 16314576

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External links

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