Pleural effusion

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Template:DiseaseDisorder infobox | }} Image:Pleural effusion.jpg Pleural effusion is excess fluid that accumulates in the pleural cavity, the fluid-filled space that surrounds the lungs.

Four types of fluids can accumulate in the pleural space:

Contents

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Pathophysiology

Healthy individuals have less than 10 ml of fluid in each pleural space. Normally, fluid enters the pleural space from the capillaries in the parietal pleura, from interstitial spaces of the lung via the visceral pleura, or from the peritoneal cavity through small holes in the diaphragm. This fluid is normally removed by lymphatics in the parietal pleura, which have the capacity to absorb 20 times more fluid than is normally formed. When this capacity is overwhelmed, either through excess formation or decreased lymphatic absorption, a pleural effusion develops.

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Diagnosis

Pleural effusion is diagnosed by chest x-ray. Chest films acquired in the lateral decubitus position (with the patient lying on her side) are more sensitive, and can pick up as little as 50 ml of fluid. At least 300 ml of fluid must be present before upright chest films can pick up signs of pleural effusion (e.g., blunted costophrenic angles). Once accumulated fluid is more than 500 ml, there are usually detectable clinical signs in the patient, such as decreased movement of the chest on the affected side, dullness to percussion over the fluid, diminished breath sounds on the affected side, decreased vocal fremitus and resonance, pleural friction rub, and egophony.

Once a pleural effusion is diagnosed, the cause must be determined. Pleural fluid is drawn out of the pleural space in a process called thoracentesis. A needle is inserted through the back of the chest wall into the pleural space. The fluid may then be evaluated for the following:

  1. Chemical composition including protein, lactate dehydrogenase (LDH), albumin, amylase, pH and glucose
  2. Gram stain and culture to identifies bacterial infections
  3. Cell count and differential
  4. Cytology to identify cancer cells, but may also identify some infective organisms
  5. Other tests as suggested by the clinical situation - lipids, fungal culture, viral culture, specific immunoglobulins
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Transudate vs. exudate

The first step in the evaluation of pleural fluid is to determine whether the effusion is a transudate or an exudate. Transudative pleural effusions are caused by systemic factors that alter the balance of the formation and absorption of pleural fluid (e.g., left ventricular failure, pulmonary embolism, and cirrhosis), while exudative pleural effusions are caused by alterations in local factors that influence the formation and absorption of pleural fluid (e.g., bacterial pneumonia, cancer, viral infection, and pulmonary embolism).

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Light's criteria

Transudative and exudative pleural effusions are differentiated by comparing protein and lactate dehydrogenase levels in the pleural fluid to those in the blood. Exudative pleural effusions meet at least one of the following criteria (Light's criteria), whereas transudative pleural effusions meet none:

  1. The ratio of pleural fluid protein to serum protein is greater than 0.5
  2. The ratio of pleural fluid LDH and serum LDH is greater than 0.6
  3. Pleural fluid LDH is more than two-thirds normal upper limit for serum

Twenty-five percent of patients with transudative pleural effusions are mistakenly identified as having exudative pleural effusions by Light's criteria. Therefore, additional testing is needed if a patient identified as having an exudative pleural effusion appears clinically to have a condition that produces a transudative effusion. In such cases albumin levels in blood and pleural fluid are measured. If the difference between the albumin levels in the blood and the pleural fluid is greater than 1.2 g/dL (12 g/L), it can be assumed that the patient has a transudative pleural effusion.

If the fluid is definitively identified as exudative, additional testing is necessary to determine the local factors causing the exudate.

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Exudative pleural effusions

Once identified as exudative, additional evaluation is needed to determine the cause of the excess fluid, and pleural fluid amylase, glucose, and cell counts are obtained. The fluid is also sent for Gram staining and culture, and, if suspicious for tuberculosis, examination for TB markers (adenosine deaminase > 45 IU/L, interferon gamma > 140 pg/mL, or positive polymerase chain reaction (PCR) for tuberculous DNA).

Pleural fluid amylase is elevated in cases of esophageal rupture, pancreatic pleural effusion, or cancer. Glucose is decreased with cancer, bacterial infections, or rheumatoid pleuritis. If cancer is suspected, the pleural fluid is sent for cytology. If cytology is negative, and cancer is still suspected, either a thoracoscopy, or needle biopsy of the pleura may be performed.

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Causes

In the United States, the most common causes of transudative pleural effusions in the United States are left ventricular failure, pulmonary embolism, and cirrhosis (causing hepatic hydrothorax), while the most common causes of exudative pleural effusions are bacterial pneumonia, cancer (with lung cancer, breast cancer, and lymphoma causing approximately 75% of all malignant pleural effusions), viral infection, and pulmonary embolism. Although pulmonary embolism can produce either transudative or exudative pleural effusions, the latter is more common.

Other causes of pleural effusion include, tuberculosis (the most common cause of pleural effusion in some developing countries), autoimmune disease such as systemic lupus erythematosus, bleeding (often due to chest trauma), chylothorax (most commonly caused by trauma), and accidental infusion of fluids. Less common causes include, esophageal rupture or pancreatic disease, intraabdominal abscess, asbestos pleural effusion, Meigs syndrome (ascites and pleural effusion due to a benign ovarian tumor), and ovarian hyperstimulation syndrome.

Pleural effusions may also occur through medical interventions, including the use of medications (pleural fluid is usually eosinophilic), coronary artery bypass surgery, abdominal surgery, endoscopic variceal sclerotherapy, radiation therapy, liver or lung transplantation, and intravascular insertion of central lines.

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Treatment

Treatment depends on the underlying cause of the pleural effusion.

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See also

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External links

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References

  • {{cite book 
| author = Light RW
| year = 2001
| title = Pleural Diseases
| edition = 4th ed.
| publisher = Lippincott Williams & Wilkins
| location = New York

}} ISBN 0781727774

  • {{cite book 
| author = Light RW
| year = 2005
| title = Harrison's Principles of Internal Medicine
| chapter = Chapter 245: Disorders of the pleura, mediastinum, diaphragm, and chest wall
| editor = Kasper DL, Braunwald E, Fauci A, Hauser S, Longo D, Jameson JL
| edition = 16th ed.
| publisher = McGraw-Hill Professional
| location = New York, NY

}} ISBN 0071402357

  • {{cite book 
| author =Dowdeswell IRG
| year = 1998
| title = Internal Medicine
| chapter = Chapter 64: Pleural Diseases
| editor = Stein JH
| edition = 5th ed.
| publisher = C.V.Mosby
| location = New York

}} ISBN 0815186983

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