Dicer
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Image:DICER.jpg Dicer is an RNAse III nuclease which cuts dsRNA into siRNAs. The structure of Dicer is an elongated molecule with a PAZ domain on one end and duel RNase III domains on the opposing end. Dicer works by recognizing the ends of dsRNA with its PAZ domain and then cutting the dsRNA with its RNase III domains. The distance between the PAZ and RNase III domains determines the length of the siRNA produced by Dicer, which is typically about 25 nucleotides.
