Succinyl-CoA
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Image:Succinyl-CoA.pngSuccinyl-Coenzyme A, generally abbreviated as Succinyl-CoA is a combination of succinic acid and coenzyme A.
Source
It is an important intermediate in the citric acid cycle, where is it synthetised from α-Ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.
Fate
It is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase.
Another fate of succinyl-CoA is porphyrin synthesis, where succinyl-CoA and glycine are combined by ALA synthase to form δ-aminolevulinic acid (dALA).
Formation
Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.