ASPM

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ASPM is a gene located on human chromosome 1, band q31 (1q31) which is associated with autosomal recessive primary microcephaly. "ASPM" is an acronym for "Abnormal Spindle-like, Microcephaly-associated", which reflects its being an ortholog to the Drosophila melanogaster "abnormal spindle" (asp) gene.

The mouse gene, Aspm, is expressed in the primary sites of prenatal cerebral cortical neurogenesis. The difference between Aspm and ASPM is a single, large insertion coding for so-called IQ domains.Template:Ref

According to recent research regarding human evolution and cultural development, the ASPM gene variation arose about 5,800 years ago, roughly correlating with the development of written language, spread of agriculture and development of cities.Template:RefTemplate:Ref

References and notes

1. Template:Note An IQ domain is a segment of DNA that codes for the IQ motif.

   IQ protein motif: [FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY]

   The term "IQ" refers to the first two amino acids of the motif: isoleucine (commonly) and glutamine (invariably).

2. Template:Note {{cite journal

 |author=Nitzan Mekel-Bobrov et al.
 |title=Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens
 |journal=Science
 |year=2005
 |volume=309
 |issue=5741
 |pages=1720–1722 
 |url=http://www.sciencemag.org/cgi/content/short/309/5741/1720}}

1. Template:Note following is one of a large number of similar news articles:

   {{cite web

 |title=Study Suggests Human Brains Still Evolving
 |work=Live Science: Human Biology
 |url=http://www.livescience.com/humanbiology/ap_050908_brain.html 
 |accessdate=November 26
 |accessyear=2005}}

1. {{cite web

 |author=Kniffin, Cassandra L. et al.
 |title=ABNORMAL SPINDLE-LIKE, MICROCEPHALY-ASSOCIATED; ASPM
 |work=OMIM at the NCBI
 |url=http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605481
 |accessdate=August 6
 |accessyear=2005 }}Template:Genetics-stub