Guanylate cyclase
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Guanylate cyclase (Template:EC number, also known as guanylyl cyclase or GC) is a lyase, an enzyme that catalyzes the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate. There are soluble and membrane-bound forms of guanylyl cyclases. Soluble GC (sGC) is activated by nitric oxide, most notably involved in vasodilation. Membrane-bound forms are receptors: GC-A & GC-B for natriuretic factors such as atrial natriuretic factor (ANF), and GC-C for guanylin. It can also be regulated by calcium.