Thelarche
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Thelarche is the first stage of secondary (postnatal) breast development, usually occurring at the beginning of puberty in girls. Thelarche is usually noticed as a firm, tender lump directly under the center of the nipple (papilla and areola). Thelarche is also referred to as a "breast bud", or more formally as Tanner stage 2 breast development (Tanner stage 1 being the entirely undeveloped prepubertal state). Thelarche may occur on one side first, or both sides simultaneously.
Thelarche is usually the first physical change of puberty in girls, and is a result of rising levels of estradiol.
When thelarche occurs at an unusually early age, it may be the first manifestation of precocious puberty. If no other changes of puberty or sex hormone effects occur, it is referred to as isolated premature thelarche, and needs no treatment.
Although breast development can occur as a part of normal male puberty, it is termed gynecomastia, and the term "thelarche" is not used with reference to male breast development.