Thermogenesis

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Thermogenesis is the process of heat production. Non-shivering thermogenesis usually occurs in brown adipose tissue (brown fat) that is present in newborn and hibernating mammals and in human infants. It is a process where substances such as free fatty acids (derived from triacylglycerols) remove purine (ADP,GDP...) inhibition of thermogenin (uncouping protein-1) which causes an influx of H+ into the matrix of the mitochondria and bypasses the ATP synthase channel. This uncouples oxidative phosphorylation and the energy from the proton motive force is dissipated as heat rather than producing ATP from ADP.

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