Chlorphenamine
From Free net encyclopedia
|
Image:Chlorphenamine.png | |
| (3RS)-3-(4-chlorophenyl)-N,N-dimethyl- 3-(pyridin-2-yl)propan-1-amine | |
| CAS number 132-22-9 | ATC code R06AB04 |
| Chemical formula | C16H19ClN2 |
| Molecular weight | 274.8 |
| Bioavailability | 25-50% |
| Metabolism | hepatic |
| Elimination half-life | 6.3-23.1 hours |
| Excretion | renal |
| Pregnancy category | Category A (Australia) |
| Legal status | Schedule 3 (Australia) |
| Routes of administration | oral, intravenous |
Chlorphenamine (INN) or chlorpheniramine (USAN, former BAN), commonly marketed as its salt chlorphenamine maleate (CPM; Chlor-Trimeton®, Piriton®), is a first-generation antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria.
Chlorphenamine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, the Swedish company Astra AB was able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from chlorphenamine.
[edit]
See also
[edit]
References
- Bruce G. Charlton, Self-management of psychiatric symptoms using over-the-counter (OTC) psychopharmacology: the S-DTM therapeutic model - self-diagnosis, self-treatment, self-monitoring. Medical Hypotheses 2005; 65: 823-828.