Diclofenac
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Image:Diclofenac.png | |
| 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid | |
| CAS number 15307-86-5 | ATC code M01AB05, M02AA15, S01BC03 |
| Chemical formula | C14H10Cl2NO2 |
| Molecular weight | 296.152 |
| SMILES | Clc2cccc(Cl)c2Nc1ccccc1CC([O-])=O |
| Bioavailability | approx. 50 to 60%, depending on mode of application |
| Metabolism | hepatic, no active metabolites exist |
| Elimination half life | 1.2-2 hr (35% of the drug enters enterohepatic recirculation) |
| Excretion | biliar, only 1% in urine |
| Pregnancy category | B (1st. and 2nd. trimenon), X (third trimenon) |
| Legal status | most preparations Rx-only, not a controlled substance |
| Routes of Application | oral, rectal, i.m.-injection, i.v.-injection (renal- and gallstones), topical |
Diclofenac (marketed as Voltaren®, Voltarol®, Diclon® and Cataflam®) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation, such as in arthritis or acute injury. It can also be used to reduce menstrual pain.
Voltaren and Voltarol contain the sodium salt of diclofenac. In the United Kingdom Voltarol can be supplied with either the sodium salt or potassium salt, while Cataflam in some other countries is the potassium salt only. Diclofenac is available in stomach acid resistant formulations (25 and 50 mg), fast disintegrating oral formulations (50 mg), slow- and controlled-release forms (75, 100 or 150 mg), suppositories (50 and 100 mg), and injectable forms (50 and 75 mg). Diclofenac is also available over the counter (OTC) in some countries: Voltaren® dolo (12.5 mg diclofenac as potassium salt) in Switzerland and Germany, and preparations with 25 mg diclofenac are OTC in New Zealand. OTC use is approved for minor aches and pains and fever associated with common infections.
Diclofenac is available as a generic drug in a number of formulations.
As reported in mainstream newsTemplate:Ref, Veterinary diclofenac use in India has caused a crash of the vulture population, with "major ecological consequences" and a sub-cultural Zoroastrian Parsi "sky burial" crisisTemplate:Ref. Diclofenac causes kidney failure in vultures that eat treated domestic animals. (See Ecological_problems)
Diclofenac is well-tolerated after 30 years experience by the general human population, but may unexpectedly become intolerated in some of the elderly population of long term users.
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Mechanism of action
The action of one single dose is much longer (6 to 8 hours) than the very short half-life of the drug indicates. This could partly be due to a particular high concentration achieved in synovial fluids.
The exact mechanism of action is not entirely known, but it is thought that the primary mechanism responsible for its anti-inflammatory/antipyretic/analgesic action is inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX).
Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have therefore a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
Diclofenac may also be a unique member of the NSAIDs. There is some evidence that diclofenac inhibits the lipooxygenase pathways, thus reducing formation of the leukotrienes (also pro-inflammatory autacoids). There is also speculation that diclofenac may inhibit phospholipase A2 as part of its mechanism of action. These additional actions may explain the high potency of diclofenac - it is the most potent NSAID on a molar basis.
There are marked differences among NSAIDs in their selective inhibition of the two subtypes of cyclo-oxygenase, COX-1 and COX-2. Much pharmaceutical drug design has attempted to focus on selective COX-2 inhibition as a way to minimize the gastrointestinal side effects of non-selective NSAIDs like aspirin. In practice, use of some COX-2 inhibitors has led to massive numbers of patient family lawsuits alleging wrongful death by heart attack, yet other significantly COX-selective NSAIDs like diclofenac have been well-tolerated by most of the population.
Common uses
Diclofenac is used for musculoskeletal complaints, especially arthritis (rheumatoid arthritis, osteoarthritis, spondylarthritis, ankylosing spondylitis), gout attacks, and pain management in case of kidney stones and gallstones. An additional indication is the treatment of acute migraines. Diclofenac is used commonly to treat mild to moderate post-operative or post-traumatic pain, particular when inflammation is also present, and is effective against menstrual pain.
As long-term use of diclofenac and similar NSAIDs predisposes for peptic ulcer, many patients at risk for this complication are prescribed a combination (Arthrotec®) of diclofenac and misoprostol, a synthetic prostaglandin analogue, to protect the gastric mucosa.
An external, gel-based form of diclofenac (Solareze®) is available for the treatment of facial actinic keratosis which is caused by over-exposure to sunlight. Some countries have also approved the external use of diclofenac gel to treat muskoskeletal conditions.
Over-the-counter use against minor aches and pains and fever associated with common infections is also licensed in some countries.
In many countries eye-drops are sold to treat acute and chronic non-bacterial inflammations of the anterior part of the eyes (e.g. postoperative states). A common brand name is Voltaren-ophta®.
Off label/investigational uses
Diclofenac is often used to treat chronic pain associated with cancer, particular if inflammation is also present (Step I of the World Health Organisation (WHO) Scheme for treatment of chronic pain). Good results (sometimes better than those with opioids) have been seen in female breast cancer and in the pain associated with bony metastases. Diclofenac can be combined with opioids if needed. In Europe Combaren® exists, a fixed combination of diclofenac and codeine (50 mg each) for cancer treatment. Combinations with psychoactive drugs such as chlorprothixene and/or amitriptyline have also been investigated and found useful in a number of cancer patients.
Fever due to malignant lymphogranulomatosis (Hodgkin's lymphoma) often reponds to diclofenac. Treatment can be terminated as soon as the usual treatment with radiation and/or chemotherapy causes remission of fever.
Diclofenac may prevent the development of Alzheimer's disease if given daily in small doses during many years. All investigations were stopped after it was found that some of the other investigated NSAIDs (naproxen, rofecoxib) caused a higher incidence of death cases due to cardiovascular events and stroke compared to placebo.
Diclofenac has been found to increase the blood pressure in patients withs Shy-Drager syndrome (autonomous hypotension) often seen in diabetic patients. Currently, this use is highly investigational and cannot be recommended as routine treatment.
Contraindications
- Hypersensitivity against diclofenac
- History of allergic reactions (bronchospasm, shock, rhinitis, urticaria) following the use of Aspirin or another NSAID
- Third-trimester pregnancy
- Active stomach and/or duodenal ulceration or gastrointestinal bleeding
- Inflammative intestinal disorders such as Crohn's disease or ulcerative colitis
- Severe insufficiency of the heart (NYHA III/IV)
- Recently, a warning has been issued by FDA not to treat patients recovering from heart surgery
- Severe liver insufficiency (Child-Pugh Class C)
- Severe renal insufficiency (creatinine clearance <30 ml/min)
- Caution in patients with preexisting hepatic porphyria, as diclofenac may trigger attacks
- Caution in patients with severe, active bleeding such as cerebral hemorrhage
Side effects
- Diclofenac is among the better tolerated NSAIDs. Though 20% of patients on long-term treatment experience side effects, only 2% have to discontinue the drug, mostly due to gastrointestinal complaints.
- Gastrointestinal complaints are most often noted (see above). The development of ulceration and/or bleeding requires immediate termination of treatment with diclofenac. Most patients receive an ulcer-protective drug as prophylaxis during long-term treatment (misoprostol, ranitidine 150mg at bedtime or omeprazole 20 mg at bedtime).
- Bone marrow depression is noted infrequently (leukopenia, agranulocytosis, thrombopenia with/without purpura, aplastic anemia). These conditions may be life-threatening and/or irreversible, if detected too late. All patients should be monitored closely. Diclofenac is a weak and reversible inhibitor of thrombocytic aggregation needed for normal coagulation.
- Liver and renal damage occur infrequently, but are usually reversible. Hepatitis may occur rarely without any warning symptoms and may be fatal. Patients with osteoarthritis develop more often symptomatic liver disease than patients with rheumatoid arthritis. Liver and kidney function should be monitored regularly during long-term treatment. If used for the shortterm treatment of pain or fever, diclofenac has not been found to be more hepatotoxic than other NSAIDs.
- Diclofenac is specifically known to cause kidney failure in Asian vultures (See Environmental_problems). Species and individual humans that are drug sensitive are initially assumed to lack genes expressing specific drug detoxification enzymes. Because elderly humans have reduced expression levels of all enzymes, elderly human metabolisms may gradually approach those of vultures, thus unexpectedly becoming more diclofenac intolerant.
- NSAIDs "are associated with adverse renal [kidney] effects caused by the reduction in synthesis of renal prostaglandins"Template:Ref in sensitive persons or animal species, and potentially during long term use in non-sensitive persons if resistance to side effects decreases with age. Unfortunately this side effect can't be avoided merely by using a COX-2 selective inhibitor because, "Both isoforms of COX, COX-1 and COX-2, are expressed in the kidney... Consequently, the same precautions regarding renal risk that are followed for nonselective NSAIDs should be used when selective COX-2 inhibitors are administered."Template:Ref (Brater, 2002)
Ecological problems
Use of diclofenac in animals has been reportedTemplate:Ref to have led to a sharp decline in the vulture population in the Indian subcontinent, up to 95% in some areas. The mechanism is probably renal failure, a known side-effect of diclofenac. Vultures eat the carcasses of domesticated animals that have been administered veterinary diclofenac, and are poisoned by the accumulated chemical. At a meeting of the National Wildlife Board in March 2005, the Government of India announced that it intended to phase out the veterinary use of diclofenacTemplate:Ref. Meloxicam is a safer (though more expensive) candidate to replace use of diclofenacTemplate:Ref.
"The loss of tens of millions of vultures over the last decade has had major ecological consequences across the Indian subcontinent that pose a potential threat to human health. In many places, populations of feral dogs (Canis familiaris) have benefited from the disappearance of Gyps vultures as the main scavenger of wild and domestic ungulate carcasses. Associated with the rise in dog numbers is an increased risk of human cases of rabies."Template:Ref (Swan, 2006)
The Government of India cites one of those major consequences as a vulture species extinction.Template:Ref Westerners may not initially appreciate how a major shift in transfer of corpse pathogens from vultures to feral dogs and rats can lead to a disease pandemic causing millions of deaths in a crowded country like India.
The loss of vultures has had a social impact on the Indian Zoroastrian Parsi community, who traditionally use vultures to dispose of human corpses in "sky burials", and are now having to seek alternative disposal methodsTemplate:Ref.
References
- Template:NoteIndia's Vultures Fall Prey to a Drug in the Cattle they Feed On New York Times, Amelia Gentleman, Published March 28, 2006.
- Template:Note Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Chaudhry MJ, Arshad M, Mahmood S, Ali A, Khan AA. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 2004;427:630-3. PMID 14745453.
- Template:Note Singhal AK, Saving the vultures from extinction. Public Information Bureau, Government of India. Accessed 15 December 2005.
- Template:Note Swan G, et al., Removing the Threat of Diclofenac to Critically Endangered Asian Vultures. PLoS Biology (journal) March 2006; v.4: i.3. (Open Access)
- Template:Note Brater DC, Renal effects of cyclooxygyenase-2-selective inhibitors. J Pain Symptom Manage. 2002 Apr;23(4 Suppl):S15-20; discussion S21-3. PMID: 11992745 Pubmed abstractde:Diclofenac