Ezetimibe
From Free net encyclopedia
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Image:Ezetimibe.png | |
| (3R,4S)-1-(4-fluorophenyl)- 3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4- (4-hydroxyphenyl)-2-azetidinone | |
| CAS number 163222-33-1 | ATC code C10AX09 |
| Chemical formula | C24H21F2NO3 |
| Molecular weight | 409.4 |
| Bioavailability | 35-65% |
| Metabolism | Glucuronidation up to 90% |
| Elimination half life | ? |
| Excretion | Biliary (78%) and renal (11%) |
| Pregnancy category | C |
| Legal status | ? |
| Delivery | Oral tablets 5, 10, 20 mg (UK - 10mg only) |
Ezetimibe (IPA: Template:IPA) (Zetia®, Ezemibe®, Ezetrol®) is an anti-hyperlipidemic medication. It acts by decreasing cholesterol absorption in the intestine. It is used together with statins (e.g. ezetimibe/simvastatin) to help lower cholesterol in patients who cannot be controlled on statins alone.
Ezetimibe binds to Niemann-Pick C1 like 1 protein on the gastrointestinal tract epithelium. This protein is required to transport cholesterol into the cells; hence ezetimibe blocks absorption.
The complete prescribing information for Zetia can be found at http://www.zetia.com/ezetimibe/zetia/consumer/product_information/pi/index.jsp