Genome annotation
From Free net encyclopedia
Genome annotation is the process of attaching biological information to sequences. It consists of two main steps. First, identitfying elements on the genome, and second attaching biological information to these elements. Automatic annotation tools try to perform all this by computer analysis, as opposed to manual annotation which involves human expertise. Ideally, these approaches co-exist and complement each other in the same annotation pipeline.
Structural annotation consists in the identification of genomic elements.
- ORFs and their localisation
- gene structure
- coding regions
- location of regulatory motifs
Functional annotation consists in attaching biological information to genomic elements.
- biochemical function
- biological function
- involved regulation and interactions
- expression
These steps may involve both biological experiments and in silico analysis.
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