Hydrolase

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In biochemistry, a hydrolase is an enzyme that catalyzes the hydrolysis of a chemical bond. For example, an enzyme that catalyzed the following reaction is a hydrolase:

A–B + H₂O → A–OH + B–H

Contents 1 Nomenclature 2 Classification 3 See also 4 References

Nomenclature

Systematic names of hydrolases are formed as "substrate hydrolase." However, common names are common, using only "substratease." For example, a nuclease is a hydrolase that cleaves nucleic acids.

Classification

Hydrolases are classified as EC 3 in the EC number classification of enzymes. Hydrolases can be further classified into several subclasses, based upon the bonds they act upon:

• EC 3.1: ester bonds (esterases)
• EC 3.2: sugars (glycosylases)
• EC 3.3: ether bonds
• EC 3.4: peptide bonds (peptidases)
• EC 3.5: carbon-nitrogen bonds, other than peptide bonds
• EC 3.6: acid anhydrides
• EC 3.7: carbon-carbon bonds
• EC 3.8: halide bonds
• EC 3.9: phosphorus-nitrogen bonds
• EC 3.10: sulfur-nitrogen bonds
• EC 3.11: carbon-phosphorus bonds
• EC 3.12: sulfur-sulfur bonds
• EC 3.13: carbon-sulfur bonds

See also

• Isomerase
• Ligase
• Esterase
• Lyase
• Oxidoreductase
• Transferase
• List of enzymes (hydrolases)

References

• EC 3 Introduction from the Department of Chemistry at Queen Mary University of London, only covers 3.1-3.4
• More detailed taxonomybg:Хидролаза

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