SERCA
From Free net encyclopedia
SERCA stands for Sarco/Endoplasmic Reticulum Ca2+-ATPase
SERCA resides in the sarcoplasmic reticulum (SR) within muscle cells. It is a Ca2+ ATPase which transfers Ca2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis. The are 3 major isoforms SERCA1-3 which are expressed a various levels in different muscle types. The rate at which SERCA moves Ca2+ across the SR membrane can be controlled by phospholamban (PLB/PLN) under ß-adrenergic stimulation. When PLB is associated with SERCA, the rate of Ca2+ movement is reduced, upon dissociation of PLB Ca2+ movement increases.