SLE

SLE can mean:

Shore Line East commuter rail service in Connecticut, USA
McNary Field, Salem, Oregon's Municipal Airport. It's IATA Airport Code
Systemic lupus erythematosus, a multisystem disease of humans
Single Loss Expectancy in risk analysis
Stochastic Loewner Evolution
Seletar Expressway, a major highway in the northeast of Singapore
Spearhead Land Element, the 'Extremely high readiness' infantry battalion of the British armed forces that is first to deploy in anywhere in time of need.
Structured Liberal Education, a department and humanities program for freshmen at Stanford University