Targeting (biology)
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- This page discusses targeting in biology. For other uses of the word, see Targeting (disambiguation).
Targeting is the process of directing proteins to specific cellular locations. This can be obtained by adding signal sequences. These signals usually involve (but are not limited to) the N-terminus of the polypeptide and have certain sequences of amino acids, also called localization signals.
Targeting can be done to:
- the nucleus, using a nuclear localization signal (NLS)
- the nucleolus, using a nucleolar localization signal (NoLS or NOS)
- the mitochondrion using a mitochodrial localization signal (MTS)
- the endoplasmic reticulum
- the peroxisome, using a peroxisomal targeting signal (PTS), this one is fused to the C-terminus.
- the chloroplast
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