Cole was primarily a painter of landscapes, but he also painted allegorical works. The most famous of these are the five-part series, "The Course of Empire", now in the collection of the New-York Historical Society and the four-part "Voyage of Life." There are two versions of the latter, one at the National Gallery in Washington, D.C., the other at the William-Munson-Proctor Museum in Ithaca, New York.
Cole influenced his artistic peers, especially Asher B. Durand and Frederic Edwin Church, who studied with Cole from 1844 to 1846. Cole spent the years 1829 to 1832 and 1841-1842 abroad, mainly in England and Italy; in Florence lived with the sculptor Horatio Greenough. After 1827 he had a studio in Catskill, New York. In 1836 he married Maria Bartow of Catskill and became a year-round resident. He died at Catskill on 11 February 1848.
Cole dabbled in architecture, a not uncommon practice at the time when the profession was not so codified. Cole was an entrant in the design competion held in 1838 to create a new state government building in Columbus, Ohio. His entry won third premium, and many contend that the finished building, a composite of the first, second and third place entries, bears a great similarity to Cole's entry.
The Voyage of Life Old Age (1842)
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Angels Ministering to Christ in the Wilderness (1843)
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Autumn Landscape (Mount Chocorua) (1827-28)
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View of Monte Video Seat of Daniel Wadsworth Esq (1828)
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The Oxbow (The Connecticut River near Northampton) (1836)
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The Garden of Eden (1828)
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The Cross and the World Study for -The Pilgrim of the World on His Journey (1846-48)
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L-Allegro (Italian Sunset) (1845)
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Indian at Sunset (1845-47)
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Romantic Landscape with Ruined Tower (1832-36)
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Frenchman's Bay Mt. Desert Island (1844)
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The Vale and Temple of Segesta Sicily
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The Course of Empire The Arcadian or Pastoral State (1836)
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Scene from -Manfred (1833)
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The Subsiding of the Waters of the Deluge (1829)
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The Course of Empire The Savage State (1836)
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View on the Catskill Early Autumn (1837)
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The Architect's Dream (1840)
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Interior of the Colosseum Rome (1832)
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View in the White Mountains (1827)
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Autumn in the Catskills (1827)
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The Voyage of Life Manhood (1840)
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The Temple of Segesta with the Artist Sketching (1843)
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Schroon Mountain Adirondacks (1838)
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Catskill Landscape (1846)
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American Lake Scene (1844)
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The Cross and the World Study for -The Pilgrim of the Cross at the End of His Journey (1846-48)
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Indian Pass Tahawus (1847)
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Morning Mist Rising Plymouth New Hampshire (A View in the United States of American in Autunm) (1830)
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Expulsion from the Garden of Eden (1828)
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View of Florence from San Miniato (1837)
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The dream of the architect 210 Sun Unedited
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Mount Aetna from Taormina (1844)
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Mountain Sunrise Catskill (1826)
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Expulsion Moon and Firelight (1828)
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The Voyage of Life Childhood (1842)
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Landscape Composition Saint John in the Wilderness (1827)
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Catskill Mountain House The Four Elements (1843-44)
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The Course of Empire Desolation (1836)
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Sunrise in the Catskill Mountains (1826)
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Falls of Kaaterskill (1826)
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Sunny Morning on the Hudson River (1827)
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Italian Scene Composition (1833)
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The Vale and Temple of Segesta Sicily (1844)
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The Consummation The Course of the Empire (1836)
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The Hunter's Return (1845)
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View Across Frenchman's Bay from Mount Desert Island After a Squall (1845)
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The Cross and the World Study for -The Pilgrim of the World at the End of His Journey (1846-48)
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The Cross and the World Study (1846-48)
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Landscape with Dead Tree (1828)
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Mount Chocorua New Hampshire (1827)
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The Course of Empire Destruction (1836)
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Daniel Boone Sitting at the Door of His Cabin on the Great Osage Lake Kentucky (1826)
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The Clove Catskills (1827)
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A View near Tivoli (Morning) (1832)
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Aqueduct near Rome (1832)
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View in the White Mountains c1827
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Landscape the Seat of Mr. Featherstonhaugh in the Distance (1826)
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The Voyage of Life Youth (1842)
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Lake with Dead Trees (Catskill) (1825)
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Prometheus Bound (1846-47)
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Portage Falls on the Genesee (1839)
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Valley of the Vaucluse (1841)
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Gelyna (View near Ticonderoga) (1826-29)
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Mount Etna from Taormina (1843)
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The Gardens of the Van Rensselaer Manor House (1840)
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River in the Catskills (1843)
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River in the Catskills (1843)
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The Gardens of the Van Rensselaer Manor House (1840)
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Mount Etna from Taormina (1843)
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Gelyna (View near Ticonderoga) (1826-29)
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Valley of the Vaucluse (1841)
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Portage Falls on the Genesee (1839)
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A View near Tivoli (Morning) (1832)
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The Clove Catskills (1827)
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Prometheus Bound (1846-47)
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Lake with Dead Trees (Catskill) (1825)
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The Voyage of Life Youth (1842)
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Landscape the Seat of Mr. Featherstonhaugh in the Distance (1826)
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View in the White Mountains c1827
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Aqueduct near Rome (1832)
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View Across Frenchman's Bay from Mount Desert Island After a Squall (1845)
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Daniel Boone Sitting at the Door of His Cabin on the Great Osage Lake Kentucky (1826)
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Landscape Composition Saint John in the Wilderness (1827)
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The Course of Empire Destruction (1836)
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Mount Chocorua New Hampshire (1827)
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Landscape with Dead Tree (1828)
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The Cross and the World Study (1846-48)
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The Cross and the World Study for -The Pilgrim of the World at the End of His Journey (1846-48)
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The Hunter's Return (1845)
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The Consummation The Course of the Empire (1836)
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The Voyage of Life Childhood (1842)
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The Vale and Temple of Segesta Sicily (1844)
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Italian Scene Composition (1833)
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Sunny Morning on the Hudson River (1827)
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Falls of Kaaterskill (1826)
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Sunrise in the Catskill Mountains (1826)
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The Course of Empire Desolation (1836)
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Catskill Mountain House The Four Elements (1843-44)
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Expulsion Moon and Firelight (1828)
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Mount Aetna from Taormina (1844)
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The dream of the architect 210 Sun Unedited
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Mountain Sunrise Catskill (1826)
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View of Florence from San Miniato (1837)
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Expulsion from the Garden of Eden (1828)
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Morning Mist Rising Plymouth New Hampshire (A View in the United States of American in Autunm) (1830)
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Indian Pass Tahawus (1847)
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The Cross and the World Study for -The Pilgrim of the Cross at the End of His Journey (1846-48)
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American Lake Scene (1844)
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Catskill Landscape (1846)
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Schroon Mountain Adirondacks (1838)
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The Voyage of Life Old Age (1842)
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The Temple of Segesta with the Artist Sketching (1843)
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The Voyage of Life Manhood (1840)
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Autumn in the Catskills (1827)
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View in the White Mountains (1827)
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Angels Ministering to Christ in the Wilderness (1843)
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Interior of the Colosseum Rome (1832)
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The Architect's Dream (1840)
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View on the Catskill Early Autumn (1837)
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The Course of Empire The Savage State (1836)
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The Subsiding of the Waters of the Deluge (1829)
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Scene from -Manfred (1833)
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The Course of Empire The Arcadian or Pastoral State (1836)
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The Vale and Temple of Segesta Sicily
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Frenchman's Bay Mt. Desert Island (1844)
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Romantic Landscape with Ruined Tower (1832-36)
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Indian at Sunset (1845-47)
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L-Allegro (Italian Sunset) (1845)
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The Cross and the World Study for -The Pilgrim of the World on His Journey (1846-48)
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The Garden of Eden (1828)
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The Oxbow (The Connecticut River near Northampton) (1836)
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View of Monte Video Seat of Daniel Wadsworth Esq (1828)
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Autumn Landscape (Mount Chocorua) (1827-28)
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